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An X-linked long non-coding RNA, <i>PTCHD1-AS</i>, and the core features of autism
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10515-6PTCHD1-AS, which encodes a long non-coding RNA, is associated with the aetiology of autism spectrum disorder in humans through …
A synaptic locus of song learning
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10510-xCombining a computational framework and optogenetic and chemogenetic manipulations within and downstream of the cortico-basal ganglia circuit identifies the …
Eosinophils drive intestinal remodelling and innate defence in reproduction
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10531-6From pregnancy until lactation, eosinophils accumulate in the small intestine where they regulate goblet cell fate and enhance innate …
Obesity rise plateaus in developed nations and accelerates in developing nations
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10383-0Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based …
Developmental gene expression patterns driving species-specific cortical features
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10491-xMachine learning analysis of cell-type-specific gene expression in mouse and human neocortex and human cortical organoids reveals human-specific cell-type …
Sleep chart of biological ageing clocks in middle and late life
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10524-5A cross-organ, multi-omics U-shaped relationship between sleep duration and biological ageing clocks highlights the potential of sleep optimization to …
Asymmetric splitting in dividing lipid-nucleotide multilamellar droplets
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10489-5Structured liquid droplets exhibit asymmetric division in the absence of reconstituted protein machinery.
Large-scale discovery, analysis and design of protein energy landscapes
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10465-zAn analysis of 5,778 domains 28–64 amino acids in length reveals hidden variation in conformational fluctuations, even between sequences …
Subspace communication in the hippocampal–retrosplenial axis
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10481-zHippocampal–neocortical communication reconfigures predetermined circuit motifs to flexibly encode experiences.
Mesoscale atomic engineering in a crystal lattice
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10431-9Electron-beam control enables deterministic placement of tens of thousands of atomic defects in three-dimensional crystals, creating stable, programmable artificial …
SNOR promotes translation restart after dormancy
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10530-7High-resolution in situ cryo-electron tomography in Schizosaccharomyces pombe identifies SNOR protein, which binds to ribosomes during dormancy induced by …
Lineage and organ signals sequentially build organ intrinsic nervous systems
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10490-ySystems-level analyses of organ intrinsic nervous systems reveal that these networks are initially configured by lineage-dependent programmes, and their …
Gaussian boson sampling with 1,024 squeezed states in 8,176 modes
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10523-6A programmable photonic quantum processor, Jiuzhang 4.0, incorporates 1,024 high-efficiency squeezed states into a hybrid spatial–temporal encoded 8,176-mode circuit.
Ecotypes of triple-negative breast cancer in response to chemotherapy
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10469-9Treatment data for triple-negative breast cancer show the importance of macrophage subtypes and cancer-cell metaprograms for interferon signalling, HLA …
Twenty-first century emergence of alpine fire in Central African mountains
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10511-wA twenty-first century fire is shown to be the first to have affected a high-elevation region in the central …
Enamel proteins from six <i>Homo erectus</i> specimens across China
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10478-8Palaeoproteomic analysis of ancient enamel proteins extracted from Middle Pleistocene Homo erectus specimens from the Zhoukoudian, Hexian and Sunjiadong …
Enhanced response of extreme compound events to cumulative CO<sub>2</sub> emissions
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10544-1A new metric shows that compound climate extremes rise faster with cumulative CO2 emissions than models project, implying higher …
State media control influences large language models
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10506-7Government-controlled media influences the output of large language models via their training data, and models queried in the languages …
Long-term editing of brain circuits using an engineered electrical synapse
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10501-yConnexin proteins found in white perch fish were used to engineer synthetic electrical synapses, enabling precision circuit editing in …
Adaptive cellular evolution in the intestine of hyperdiverse cichlid fishes
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10494-8Single-cell transcriptomics combined with morphological and ecological data show that the rapid evolutionary radiation of cichlid fishes in Lake …
Sustaining microglial reparative function enhances stroke recovery
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10480-0Reparative microglia persist in the brain after stroke but become dysfunctional through ZFP384-mediated mechanisms; however, this process can be …
Pristine Antarctic ice records the Solar System’s travels
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01505-9Rare isotopes hint at when the Solar System entered the Local Interstellar Cloud.
Red-light therapy is all the rage — does it work?
Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01547-zThere are a multitude of red-light emitting consumer goods, but do they really do anything for your health? We …
Efficient robot navigation inspired by honeybee learning flights
Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10461-3A highly efficient navigation strategy taking inspiration from the visual learning flights of honeybees is described, which enables drones …
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