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Brain lipids are organized into zones — and reorganized during pregnancy
Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02772-2A map of fats across the whole mouse brain reveals a spatial architecture that differs from that seen in …
The mutational dynamics of the <i>Arabidopsis</i> centromeres
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11046-wCentromeres in Arabidopsis thaliana evolve through frequent insertions and deletions of repeat units and increased rates of point mutations …
Organic two-dimensional van der Waals heterostructures
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11074-6Sequential on-water-surface assembly enables layer-by-layer stacking of two-dimensional polymers to create both lattice-matched and controlled lattice-mismatched van der Waals …
Neuronal detection of social actions directs collective escape behaviour
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11041-1Collective escape in Danionella cerebrum arises from visual detection of rapid, biologically realistic motion of other fish, with midbrain …
A quadruped robot designed to complete a marathon on a single battery …
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11102-5RAIBO2, an energy-efficient quadruped robot, completed a full marathon in 4 hours, 19 minutes and 52 seconds on a …
MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11048-8Stability of extrachromosomal DNA (ecDNA) relies on microhomology-mediated end joining at fragile TA-rich sites, with FANCM suppressing break formation, …
Single-cell atlas of transcriptomic vulnerability across brain disorders
Nature, Published online: 23 September 2026; doi:10.1038/s41586-025-09573-zA population-scale single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex provides a perspective of the transcriptomic landscape in …
The lipidomic architecture of the mouse brain
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11050-0A spatial lipidomic atlas of the mouse brain reveals more than 500 biochemical territories that mirror cell types and …
Lsp2 links early-life diet to adult translation and lifespan in <i>Drosophila</i>
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11031-3Isotope tracing is used to determine the fate of larval dietary amino acids in adult flies, and identifies Lsp2 …
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in <i>Drosophila</i>
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11029-xIn Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of …
TRAM promotes Toll-like-receptor-free myddosome signal transduction
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11052-yTRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and …
Stacking-induced direct band gap in CVD-grown 1H MoS<sub>2</sub> bilayers
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11069-3Atomically aligned 1H bilayer MoS2 exhibits a direct band gap, enhanced excitonic emission and stronger valley polarization, establishing its …
Agricultural liming is a carbon sink in the Mississippi River Basin
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11040-2Century-scale records of agricultural liming and anthropogenic acidity inputs for the Mississippi River Basin show that agricultural liming has …
Lifespan single-cell transcriptomic atlas of the human prefrontal cortex
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-10271-7The dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development, relative stability in midlife …
Anomalous metal and superconducting phases in rhombohedral graphene
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11033-1Observations of rhombohedral graphene on a WSe2 substrate at varying temperature, magnetic field and current indicate the presence of …
Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11059-5ZMYND8 suppresses IL-2R–STAT5 signalling by inhibiting p300-mediated transcriptional activation of Il2ra to enforce CD8+ T cell terminal exhaustion, and …
mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11054-wReactive astrocytes emerge as a primary consequence of TSC2 loss in tuberous sclerosis complex, implicating glial dysfunction as a …
Reference genomes and fossils revise bat family phylogeny and biogeography
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11007-3An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all …
A methanogen hydrolase reveals the structure of archaeal peptidoglycan
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11028-yArmA from Methanobrevibacter smithii, a dominant member of the human gut microbiome, is identified and characterized as a glycosyl …
A design approach for bitopic kinase inhibitors
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11056-8Detailed analyses of ligand choice, linkage vector and linker length enabled the development of bitopic inhibitors of ABL1 and …
Hepatocytes promote liver metastasis of pancreatic cancer by providing serine
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11051-zMetastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes …
Banking records reveal characteristics of financial abuse
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11049-7An analysis of UK banking data reveals that people who reported being victim-survivors of financial abuse experience worse financial …
Sequence-encoded hexagonal lattices in multichannel peptide nanofibrils
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11016-2Nine-residue peptides can encode discrete interaction motifs that direct the formation of hexagonal pores, which hierarchically tile into laterally …
Lu<sup>+</sup> optical frequency references with accuracy verified at the 19th digit
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11072-8Two independent 176Lu+ single-ion optical clocks achieve fractional frequency uncertainties near 10−19 and agree at 5.7 × 10−19, advancing …
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