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Topographic structure and function of locus coeruleus noradrenaline neurons
Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11026-0Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice …
Evolution and heterogeneity of lethal metastatic bladder cancer subtypes
Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11035-zA rapid autopsy programme provides valuable resources to enable detailed molecular and genetic analyses of the temporal evolution of …
Mutational constraints on RSV F and its neutralization by antibodies
Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11030-4How respiratory syncytial virus mutations affect antibody neutralization is defined, and a biophysical model of the mechanism is provided, …
Continuous-wave laser absorption spectroscopy of the thorium-229 nucleus
Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11011-7Absorption spectroscopy of thorium-229 nuclear excited states in a thorium-doped calcium fluoride crystal demonstrates a path towards a much …
Electroluminescent photoresists extending lithographic scaling to OLEDs
Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11042-0Electroluminescent photoresists synthesized via atom transfer radical polymerization can be directly patterned by ultraviolet and electron-beam lithography, and used …
Reimagining research papers as interactive and reliable AI agents
Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11044-yPaper2Agent converts research papers into interactive artificial intelligence agents by turning manuscripts, code and data into model context protocol-based …
Mitochondrial fission factor senses and governs ferroptosis
Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11020-6The mitochondrial–peroxisomal fission adaptor MFF is identified as a selective pro-ferroptotic mediator, and the newly developed MFF–SPARK sensor enables …
Developmental xenocortication using human-derived organoids in mice
Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11032-2Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.
Development of a random background to understand ligand optimization
Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11013-5An approach to improve efficiency and establish a background expectation for ligand potency optimization is described.
Transplanted human brain-tissue takes root in mice without a cortex
Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02927-1Extensive cellular integration might provide platform for in vivo testing of new therapies — plus, the AI tool that …
Why most stars don’t have outbursts like the Sun’s
Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02833-6A strong magnetic field can disrupt a star’s ability to produce the fountains of matter called coronal mass ejections.
Mechanisms of Transcriptional Regulation by Salicylic Acid Receptors
Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11123-0Mechanisms of Transcriptional Regulation by Salicylic Acid Receptors
Inflection points and transitions in Alzheimer’s disease
Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11110-5Inflection points and transitions in Alzheimer’s disease
These bizarre, much-coveted microbes are revealing the origins of complex life
Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02849-yResearchers are racing to culture a menagerie of exotic organisms and finding lots of surprises along the way.
Map of brain ‘microproteins’ could offer new clues to Alzheimer’s disease
Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02914-6Researchers detect more than 1,000 overlooked microproteins in human brain tissue, including some that are altered in Alzheimer’s disease.
The Parthenon’s architectural illusions are a myth
Optical illusions thought to have influenced the design of the Parthenon in ancient Greece are not backed up by evidence or are too small to …
We may finally have a way to rate a quantum computer’s usefulness
Determining how useful different quantum computers are has been a long running challenge – now researchers appear to have the answer
Scientists stunned as volcano cloud starts destroying methane
The Hunga Tonga eruption may have triggered a surprising chemical reaction that destroyed some of the methane released into the atmosphere. Scientists say the discovery …
Smelling chocolate helped men complete more reps without feeling more tired
Simply smelling chocolate helped men complete more leg extension repetitions without making the workout feel harder, with dark chocolate producing the strongest effect. The researchers …
How better ways of screening drugs could soon lead to thousands fewer …
Scientists can now get more accurate safety data by testing drugs on organ-on-a-chip devices and organoids, meaning that there's increasingly less need to harm animals
Roman roads weren’t so straight after all
Detailed data on the Roman Empire’s entire road network is offering fresh insight into how Romans built their infrastructure and how it influenced the future …
This Australian cave hid 25,000 years of ritual secrets
Microscopic plant remains are revealing how GunaiKurnai ancestors used Cloggs Cave for ritual practices over thousands of years. People deliberately gathered whole grasses, carried them …
Scientists discover a major brain shift between ages 50 and 75
Scientists have uncovered sweeping changes in how the human brain controls and organizes its genome beginning in midlife, offering new clues to why aging sharply …
UV light reveals possible camouflage on a 125-million-year-old crocodile
A 125-million-year-old crocodile fossil has revealed preserved skin, possible sensory organs, sophisticated respiratory structures, and an unexpected pattern on its tail. Ultraviolet light exposed alternating …
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