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Science Nature News
A radical approach to making C-glycoside molecules

Nature, Published online: 22 July 2026; doi:10.1038/d41586-026-02237-6A platform for synthesizing highly desirable C-glycoside molecules from sugar has been developed that uses glycosyl sulfonyl hydrazides as …

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Genetic background sets the trajectory of experimental cancer evolution

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10821-zExperimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving …

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Mapping drivers of life expectancy change in Asia from 1990 to 2023

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10739-6Using the Global Burden of Disease Study data across Asian countries and territories, life expectancy trends and the effects …

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Efficient and precise programmable DNA knock-in without double-strand breaks

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10819-7Kilobase-scale nickase-targeting (KNIT) editing enables single-nick-based DNA insertion across genomic loci and cell types, supporting insertion of DNA fragments …

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Semiconducting and magnetic lanthanide MXenes from intercalated halides

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10802-2A bottom-up synthesis strategy creates lanthanide MXenes (Ln2CT2) that combine semiconducting behaviour with ferromagnetism, offering a promising new class …

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Brown bullhead catfish melanoma represents a novel transmissible cancer

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10828-6Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of …

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Exceptional brain and ecological diversity in the earliest snakes

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10809-9A well-preserved fossil snake from the Late Cretaceous of Brazil shows early ecological and brain shape disparity in the …

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Imaging of nanoscale polar textures in quantum paraelectric SrTiO<sub>3</sub>

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10823-xCryo-STEM reveals that SrTiO3 forms periodic polar nanodomains below 105 K, but these fragment below 40 K, linking quantum …

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Non-Gaussian statistics of the order parameter across a phase transition

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10811-1Single-atom measurements show non-Gaussian order-parameter fluctuations and critical scaling across a continuous phase transition, highlighting the importance of full …

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Subnuclear genome compartmentalization controls bivalent chromatin activity

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10832-wKnowledge of the spatial location of a gene is necessary to understand its epigenomic regulation.

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A global molecular code for birth order and neuronal identity in <i>Drosophila</i>

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10797-wA high-resolution developmental transcriptional atlas of the Drosophila melanogaster nerve cord identifies a shared transcriptional code that records neuronal …

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The planktonic microbiome of the Great Barrier Reef

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10778-zThe Great Barrier Reef Microbial Genomes Database compiles prokaryotic, viral and eukaryotic genomes from seawater collected from the Great …

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AI-redesigned starting points and outcomes enhance protein evolution

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10820-0A workflow using artificial intelligence-redesigned starting points to evolve enzymes with improved properties compared with those evolved from natural …

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Precise DNA base editing using AlphaFold3-based contact modelling

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10794-zContactSeek is an AlphaFold3-driven model that can improve the precision of genome-editing tools.

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A vector-based strategy for olfactory navigation in <i>Drosophila</i>

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10827-7Using a virtual reality system, experiments in Drosophila show that flies use memory mechanisms to navigate along the boundary …

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Tertiary lymphoid structures harbour stem-like tumour-specific T cells

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10808-wRenal cell carcinoma tumours containing tertiary lymphoid structures (TLSs) are enriched for exhausted CD8+ T cells, including tumour-specific clonotypes …

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Planetary-mass exosatellite detected around the substellar companion of a star

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10751-wRadial velocity measurements provide evidence for a Jupiter-mass exosatellite orbiting the brown dwarf companion CD-35 2722 B, a promising …

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Insulator-free topological photonic multi-lane highways

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10817-9An insulator-free topological waveguide architecture comprising four inequivalent photonic valley half-semimetals arranged in a parallel, cyclic configuration and stacked …

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Structural basis of the RNA-editing cascade in trypanosome mitochondria

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10831-xCryo-electron microscopy sheds light on the architecture of the Trypanosoma brucei mitochondrial editosome and reveals how this assembly mediates …

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Prior therapy defines mutation profiles in childhood cancer at relapse

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10803-1Chemotherapy, particularly with platinum-based drugs, is associated with substantial, rapidly detectable mutagenesis in childhood cancers, tripling private signatures and …

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Non-epitaxial perovskite polariton laser diode operating under direct current

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10824-wBy integrating a solution-grown perovskite microplate with chemically inert single-walled carbon nanotube electrodes and embedding them into an optical …

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CRISPR–Cas regulates expression of embedded anti-phage defence systems

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10833-9CRISPR–Cas systems transcriptionally tune diverse innate defences using CRISPR RNA-like guides to balance antiviral protection with fitness, and hyperactivate …

Science Nature News
Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10701-6Structural studies of Crimean–Congo haemorrhagic fever virus (CCHFV) polymerase reveal the structural basis of CCHFV RNA synthesis and highlight …

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How do quantum computers work?

Nature, Published online: 22 July 2026; doi:10.1038/d41586-026-02219-8Recent breakthroughs suggest usable devices could be here in a decade.

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