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Early fibrotic niches establish tumour-permissive microenvironments
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10399-6Pathologic transformation in KrasG12D-mutant alveolar type II cells initiates a tumour-permissive niche by orchestrating epithelial, stromal and immune reprogramming …
Mechanically driven Li dendrite penetration in garnet solid electrolyte
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10415-9Cryogenic electron microscopy images and micromechanical fracture modelling of mechanically soft lithium dendrites fracturing hard ceramic electrolytes suggest the …
Symmetry classification of magnetic orders using oriented spin space groups
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10401-1An oriented spin space group description is proposed that unifies the spin space group and magnetic space group frameworks, …
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10394-xHuman CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins …
H<sub>2</sub>O<sub>2</sub> repurposes plant O<sub>2</sub> sensing to regulate post-hypoxia responses
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10366-1Experiments in Arabidopsis demonstrate that group VII ethylene response factors show differential responses to different stimuli, enabling plants in …
Printable meta-assemblies enable synergetic colouration
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10408-8A printable meta-assembly comprising polystyrene embedded in a polydimethylsiloxane matrix used in roll-to-roll additive nanoprinting is described for the …
Chromosomal fusions trigger rediploidization of autopolyploid genomes
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10439-1Genomic data from snow carps reveal that the fusion of chromosomes initiates rediploidization following whole-genome duplication.
Glycerol-driven TNAP activation in thermogenesis and mineralization
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10396-9Glycerol is an allosteric activator of tissue-nonspecific alkaline phosphatase (TNAP), activating the futile creatine cycle.
Electronic origin of reorganization energy in interfacial electron transfer
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10311-2By tuning graphene’s electronic density of states, the study shows electrode electronic structure—not just the electrolyte—dominates reorganization energy and …
A pro-carcinogenic bacterial toxin binds claudin-4 to cleave E-cadherin
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10375-0CRISPR screening shows that claudin-4 is a receptor for the pro-carcinogenic B. fragilis toxin on colonic epithelial cells, and …
Non-equilibrium condensation of the first Solar System solids
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10257-5A time-dependent model shows chondrite precursors formed by non-equilibrium condensation: cooling rate and pressure alone generate three mineral classes …
Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10436-4The Lap-NET1 phase 1b trial reports that combined netrin1 antibody (NP137) plus modified FOLFIRINOX therapy on patients with locally …
Switchable 2D–3D display through a metasurface lenticular lens
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10318-9A full-colour 2D–3D switchable light-field display powered by a metasurface lenticular lens is proposed that is a promising solution …
Myosin forces remodel F-actin for mechanosensitive protein recognition
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10398-7Structural studies demonstrate that myosin generates forces that cause structural changes in actin, modulating cooperative binding by α-catenin and …
Efficiency-optimized relativistic plasma harmonics for extreme fields
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10400-2Tailoring relativistic laser–plasma interactions on femtosecond timescales unlocks a direct route to extreme field generation using a coherent harmonic …
Multicentre gene therapy for <i>OTOF</i>-related deafness followed up to 2.5 years
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10393-yIn a multicentre trial of AAV1-hOTOF gene therapy involving 42 participants aged 0.8–32.3 years with autosomal recessive deafness 9, …
Astrocytes connect specific brain regions through plastic networks
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10426-6Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.
Dynamics of genetic and somatic trade-offs in ageing and mortality
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10407-9Mapping DNA variants that modulate mortality using a starting population of 6,438 young mice defined 29 distinct loci that …
Focal white matter lesions drive grey matter inflammation and synapse loss
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10414-wA transient grey matter microgliosis is required for remyelination, the failure of which results in a chronic neuroinflammatory state …
Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10343-8CASP5 expression is restricted to the human intestinal epithelium, and the CASP5C isoform has a key role in promoting …
Little ants groom big ones in a desert spa
Nature, Published online: 22 April 2026; doi:10.1038/d41586-026-01237-wArizona ‘cleaner’ ant nibbles and licks the workers of a different ant species.
Meet Ace, the table-tennis robot that can beat elite players
Nature, Published online: 22 April 2026; doi:10.1038/d41586-026-01341-xA high-speed perception system allows the robot to predict complex ball movements — plus, the decade-long experiment measuring the …
This robot can beat you at table tennis
Nature, Published online: 22 April 2026; doi:10.1038/d41586-026-01343-9The AI-powered arm learnt the sport from scratch and can now beat top players.
Author Correction: Robust cytoplasmic partitioning by solving a cytoskeletal instability
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10390-1Author Correction: Robust cytoplasmic partitioning by solving a cytoskeletal instability
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