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Titan’s strong tidal dissipation precludes a subsurface ocean
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09818-xReanalysis of radiometric data from Cassini indicates that Titan does not contain a subsurface ocean, as strong tidal dissipation …
Prevalence of Alzheimer’s disease pathology in the community
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09841-yThe prevalence of Alzheimer’s disease neuropathological changes is reported based on blood-based biomarkers in a Norwegian population-based cohort.
Visualizing interaction-driven restructuring of quantum Hall edge states
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09858-3Scanning tunnelling microscopy is used to image pristine electrostatically defined quantum Hall edge states in graphene with high spatial …
The global hydrogen budget
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09806-1Trends in global H2 sources and sinks are analysed from 1990 to 2020, and a comprehensive budget for the …
An 11-qubit atom processor in silicon
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09827-wAn 11-qubit atom processor comprising two precision-placed nuclear spin registers of phosphorus in silicon is shown to achieve state-of-the-art …
Astrocyte CCN1 stabilizes neural circuits in the adult brain
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09770-wNeural circuits in adult mouse visual cortex are stabilized by astrocytes, which secrete CCN1, resulting in reduced plasticity and …
Palaeometabolomes yield biological and ecological profiles at early human sites
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09843-wMetabolic and proteomic profiles derived from fossilized skeletal remains of animals enable inferences regarding physiological health and disease as …
An integrated view of the structure and function of the human 4D …
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09890-3The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then …
Programmable 200 GOPS Hopfield-inspired photonic Ising machine
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09838-7An architecture inspired by Hopfield networks based on a programmable, stable, room-temperature optoelectronic oscillator-based photonics Ising machine is introduced …
GTP release-selective agonists prolong opioid analgesic efficacy
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09880-5Mu opioid receptor agonists with a preference for the non-GTP-bound state of the G protein promote GTP release, thereby …
Gene-specific selective sweeps are pervasive across human gut microbiomes
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09798-yDevelopment and application of the integrated linkage disequilibrium score (iLDS) reveals both selective pressures impacting the human gut microbiome …
Transient hepatic reconstitution of trophic factors enhances aged immunity
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09873-4Using lipid nanoparticle delivery of mRNAs to the liver in aged mice, T cell function and declining immune cues …
Is bird flu the next pandemic? The science so far
Nature, Published online: 17 December 2025; doi:10.1038/d41586-025-03777-zKey mutations and animal spread could raise the risk to humans.
Biobanks reveal genetic complexity in human evolution
Nature, Published online: 17 December 2025; doi:10.1038/d41586-025-04079-0Tiny genetic variations between humans, Neanderthals and Denisovans might not be all they were cracked up to be.
How the Romans built their empire of concrete
Nature, Published online: 17 December 2025; doi:10.1038/d41586-025-04080-7A unique archaeological site at Pompeii, Italy, reveals the secrets of peculiarly durable Roman building materials.
Author Correction: Neuroimmune cardiovascular interfaces control atherosclerosis
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-10043-9Author Correction: Neuroimmune cardiovascular interfaces control atherosclerosis
Mazdutide versus placebo in Chinese adults with type 2 diabetes
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-10026-wMazdutide versus placebo in Chinese adults with type 2 diabetes
Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-10031-zMazdutide versus dulaglutide in Chinese adults with type 2 diabetes
AI is transforming the economy — understanding its impact requires both data …
Nature, Published online: 16 December 2025; doi:10.1038/d41586-025-04053-wControlled studies capture only a fraction of the effects of artificial intelligence. Economists should work with social scientists to …
How my institution strengthened research despite chronic underfunding
Nature, Published online: 16 December 2025; doi:10.1038/d41586-025-04050-zNurturing research talent at community-rooted universities and colleges is a necessity, not a luxury.
Scientists skip key US meetings — and seize on smaller alternatives
Nature, Published online: 16 December 2025; doi:10.1038/d41586-025-04083-4Researchers are devising creative ways to get together as Trump’s policies curb travel to US gatherings.
Science’s role in my <i>Great British Sewing Bee</i> success
Nature, Published online: 16 December 2025; doi:10.1038/d41586-025-03536-0A research background and a passion for sewing inspired by her father helped Yasmin Proctor-Kent to reach the finals …
Safety regulations for cloning and a compass that finds true north
Nature, Published online: 16 December 2025; doi:10.1038/d41586-025-03740-yScientists discuss concerns that genetic manipulation could lead to disease outbreaks, and Nature is gifted an unusual scientific instrument, …
More than half of researchers now use AI for peer review — …
Nature, Published online: 15 December 2025; doi:10.1038/d41586-025-04066-5A survey of 1,600 academics found that more than 50% have used artificial-intelligence tools while peer reviewing manuscripts.
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