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An enzyme inside the bacterial-cell membrane chops up viral DNA on entry
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00732-4When a virus infects a bacterial cell, the viral genome is the first component to be fully injected into …
CRISPR makes enhanced cancer-fighting immune cells inside mice
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00857-6Gene-editing technique promises a potentially safer way to create CAR T cells with a simple injection.
Daily briefing: Funding calls plummet as NIH turns away from agency-directed science
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00897-yThe US National Institutes of Health will now focus on ‘unsolicited’ research proposals driven by the interests of individual …
Our microbial ancestors were probably oxygen-tolerant
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00718-2Genomic analysis has unexpectedly revealed that microorganisms called Asgard archaea, the closest relative of our cellular ancestors, can respire …
Brain’s protective barrier stays leaky for years after playing contact sports
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00885-2Damage to the blood–brain barrier is linked to immune changes and cognitive decline.
Mystery of how plants make a family of medicinal molecules has been …
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00790-8The cinchona alkaloids are a family of plant-derived compounds that include quinine, an antimalarial drug also used as the …
Quirky base pairing attracts rule-breaking enzymes to destroy microRNAs
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00632-7MicroRNAs control gene expression by modulating the output and stability of messenger RNAs. How are these crucial regulators kept …
Static electricity is a big mystery — a jolt of fresh research …
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00837-wThe familiar phenomenon has puzzled researchers for centuries, but experiments are finally making sense of its unruly behaviours.
A gene-editing method generates immunotherapeutic CAR T cells in the body
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00634-5Laboratory-engineered immune cells called CAR T cells provide effective treatment for some cancers. Progress is being made towards creating …
Leading the charge to explain static electricity
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00839-8There’s a shocking lack of understanding of the physics underlying this commonplace phenomenon, but researchers are on the case.
Hair-raising: how carbon contamination can drive static charging
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00631-8Objects made from the same insulator can sometimes acquire different charges when rubbed together, owing to a thin layer …
Genome editing that avoids immune detection to integrate large DNA sequences
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00730-6A genome-editing approach called INSTALL combines single-stranded DNA molecules that evade immune detection with a short double-stranded region that …
Climate snapshots trapped in ancient ice tell a surprising story
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00636-3Antarctic ice cores hint that changes in the ocean might have played a larger part than have greenhouse gases …
Catabolism of extracellular glutathione supplies cysteine to support tumours
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10268-2Catabolism of extracellular glutathione by γ-glutamyltransferases supports tumour growth and survival, and pharmacological targeting of these enzymes slows tumour …
A strong constraint on radiative forcing of well-mixed greenhouse gases
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10289-xComparing line-by-line transfer simulations using the radiation code GRTcode with regressions against satellite-observed ongoing longwave radiation shows that instantaneous …
Climbing fibres recruit disinhibition to enhance Purkinje cell calcium signals
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10220-4Synchronous activation of climbing fibres engages disinhibitory circuitry to promote large dendritic calcium signals in Purkinje cells that are …
Adventitious carbon breaks symmetry in oxide contact electrification
Nature, Published online: 18 March 2026; doi:10.1038/s41586-025-10088-wBy measuring charge exchange in a sphere/plate pair composed of identical amorphous silicon dioxide and controlling charging polarity using …
The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10232-0Target-directed microRNA degradation is driven by the atypical ZSWIM8–CUL3 E3 ubiquitin ligase that uses a two-RNA-factor authentication mechanism to …
Integrated photonic neural network with on-chip backpropagation training
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10262-8An integrated photonic deep neural network was trained end-to-end with on-chip gradient-descent backpropagation, and all linear and nonlinear computations …
Biosynthesis of cinchona alkaloids
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10227-xA combination of isotopic labelling, gene silencing, single-nucleus RNA sequencing and comparative transcriptomics reveal the genes that mediate the …
Proteasome-guided haem signalling axis contributes to T cell exhaustion
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10250-yExhausted CD8+ T cells increase proteasome activity due to the accumulation of depolarized mitochondria, which drives the selective degradation …
Contrasting thermophilization among forests, grasslands and alpine summits
Nature, Published online: 18 March 2026; doi:10.1038/s41586-025-09622-7Analyses of large-scale, multitaxa and long-term thermophilization patterns in forests, grasslands and alpine summits across Europe provide insight into …
Thymic health and immunotherapy outcomes in patients with cancer
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10243-xA deep-learning approach applied to routine CT scans is used to quantify the health of the thymus in a …
Global ocean heat content over the past 3 million years
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10116-3Estimates of mean ocean temperature based on noble gas (Xe/Kr) measurements in shallow ice cores from the Allan Hills …
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