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Daily briefing: ‘Virtual cell’ simulates nearly every chemical reaction in the real …
Nature, Published online: 11 March 2026; doi:10.1038/d41586-026-00815-2A new simulation models processes such as DNA replication and cell division in a virtual bacterial cell. Plus, China …
A mechanism to initiate emergency type 2 myelopoiesis
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10256-6Myelopoiesis in response to a parasitic worm infection and the mechanism selective to this form of parasite are revealed.
Gene conversion empowers natural selection in a clonal fish species
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10180-9Analysis of the asexually reproducing Amazon molly Poecilia formosa and its sexually reproducing progenitors Poecilia mexicana and Poecilia latipinna …
Risk-adaptive therapy guided by dynamic ctDNA in nasopharyngeal carcinoma
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10244-wA clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions …
Ageing promotes metastasis via activation of the integrated stress response
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10216-0Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic …
Natural maternal immunity protects neonates from <i>Escherichia coli</i> sepsis
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10225-zNeonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse …
Immune evasive DNA donors and recombinases license kilobase-scale writing
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10241-zINSTALL overcomes fundamental challenges for DNA delivery and integration methods by synergizing immune-stealth nucleic acids with recombinases to enable …
A big-push community intervention reduced rates of child marriage by 80%
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10206-2A community-wide intervention in northern Nigeria reduced rates of child marriage from 79% to 14%, showing that bundled, big-push …
Nanophotonic waveguide chip-to-world beam scanning
Nature, Published online: 11 March 2026; doi:10.1038/s41586-025-10038-6A monolithically integrated photonic ski-jump enables scalable, diffraction-limited 2D beam scanning from photonic chips, achieving ultrahigh spot rates, compact …
B cell imprinting in children impairs antibodies to the haemagglutinin stalk
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10248-6Imprinting by influenza viruses can cause a deleterious shift of nearly the entire memory recall response against key, conserved …
A sorghum pangenome reference improves global crop trait discovery
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10229-9A pangenome reference for the phenotypically diverse crop sorghum aims to help accelerate future efforts to breed crops that …
Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10215-1SUMM2, a coiled-coil NLR, promotes the assembly of higher-order resistosome clusters to initiate cell death in plants.
Intestinal interoceptive dysfunction drives age-associated cognitive decline
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10191-6Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting …
Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10120-7Time-resolved cryo-electron microscopy during activation of Gαi1βγ and Gα11βγ heterotrimers bound to NTSR1 enables isolation of multiple transient complexes …
Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10208-0A fusion protein designed to comprise IL-2 and a helminth-derived TGFβ mimic activates IL-2 and TGFβ signalling pathways in …
Lense–Thirring precessing magnetar engine drives a superluminous supernova
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10151-0Observations of a nearby type I superluminous supernova showing oscillating light-curve bumps provide evidence of a centrally located magnetar …
Multimodal electron microscopy of halide perovskite interfacial dynamics
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10238-8A multimodal in situ electron microscopy approach enables direct visualization of structural and chemical evolution in a working halide …
Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10240-0Marburgvirus glycoprotein binds to the endosomal receptor NPC1 in a distinct orientation with higher affinity compared with Ebola virus …
Multidimensional profiling of heterogeneity in supratentorial ependymomas
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10214-2Individual supratentorial ependymoma tumour subgroups have two distinct progenitor-like cell states—neuroepithelial-like and embryonic-like—that are reminiscent of early human brain …
Capturing dynamic phage–pathogen coevolution by clinical surveillance
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10136-zThe acquisition of a parasitic anti-phage mobile genetic element, PLE11, showing potent anti-phage activity against cocirculating ICP1, and the …
A large-scale coherent 4D imaging sensor
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10183-6A 4D imaging architecture using a large-scale, coherent LiDAR focal plane array comprising more than 0.6 million photonic components …
The dynamic basis of G-protein recognition and activation by a GPCR
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10228-wConventional and time-resolved cryo-electron microscopy reveal how NTSR1 dynamically engages and releases different G proteins, capturing over 20 intermediates …
This fish shouldn’t exist — the weird genetics of clonal vertebrates
Nature, Published online: 11 March 2026; doi:10.1038/d41586-026-00798-0A study reveals how the asexual Amazon molly defies evolutionary expectations — plus, evidence of what might be powering …
This supernova is too bright – now astronomers might know why
Nature, Published online: 11 March 2026; doi:10.1038/d41586-026-00801-8Wobbling signal could explain some extremely bright supernovae
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