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Adventitious carbon breaks symmetry in oxide contact electrification
Nature, Published online: 18 March 2026; doi:10.1038/s41586-025-10088-wBy measuring charge exchange in a sphere/plate pair composed of identical amorphous silicon dioxide and controlling charging polarity using …
The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10232-0Target-directed microRNA degradation is driven by the atypical ZSWIM8–CUL3 E3 ubiquitin ligase that uses a two-RNA-factor authentication mechanism to …
Integrated photonic neural network with on-chip backpropagation training
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10262-8An integrated photonic deep neural network was trained end-to-end with on-chip gradient-descent backpropagation, and all linear and nonlinear computations …
Biosynthesis of cinchona alkaloids
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10227-xA combination of isotopic labelling, gene silencing, single-nucleus RNA sequencing and comparative transcriptomics reveal the genes that mediate the …
Proteasome-guided haem signalling axis contributes to T cell exhaustion
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10250-yExhausted CD8+ T cells increase proteasome activity due to the accumulation of depolarized mitochondria, which drives the selective degradation …
Contrasting thermophilization among forests, grasslands and alpine summits
Nature, Published online: 18 March 2026; doi:10.1038/s41586-025-09622-7Analyses of large-scale, multitaxa and long-term thermophilization patterns in forests, grasslands and alpine summits across Europe provide insight into …
Thymic health and immunotherapy outcomes in patients with cancer
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10243-xA deep-learning approach applied to routine CT scans is used to quantify the health of the thymus in a …
Global ocean heat content over the past 3 million years
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10116-3Estimates of mean ocean temperature based on noble gas (Xe/Kr) measurements in shallow ice cores from the Allan Hills …
Observation of self-bound droplets of ultracold dipolar molecules
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10245-9Self-bound droplets and droplet arrays are observed in an ultracold gas of strongly dipolar sodium–caesium molecules, establishing ultracold molecules …
Bistable superlattice switching in a quantum spin Hall insulator
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10309-wBistable superlattice switching between two lattice configurations with sharply contrasting periodicities has been observed in monolayer TaIrTe4, a dual …
Local agricultural transition, crisis and migration in the Southern Andes
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10233-zIn the Uspallata Valley, agriculture was adopted by local populations, as evidenced by genetic continuity from earlier hunter-gatherers to …
Broadly stable atmospheric CO<sub>2</sub> and CH<sub>4</sub> levels over the past 3 million …
Nature, Published online: 18 March 2026; doi:10.1038/s41586-025-10032-yBlue ice records from Antarctica are used to determine methane and carbon dioxide concentrations over the past 3 million …
Adaptive evolution of gene regulatory networks in mammalian neocortex
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10226-yThe excitatory neuron diversity and specialized connectivity of complex, multilayered mammalian neocortex are driven by mammalian-specific cis-regulatory elements bound …
Thymic health consequences in adults
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10242-yAssessing thymic function and health has highlighted the lifelong importance of the thymus as an organ that could be …
Observing the tidal pulse of rivers from wide-swath satellite altimetry
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10287-zData from the recently launched SWOT satellite, a wide-swath satellite altimeter, have been used to map tidal dynamics for …
Synthetic circuits for cell ratio control
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10259-3A synthetic genetic circuit made up of recombinase-based cell-fate branching devices enables precise control over the ratios of cell …
In vivo site-specific engineering to reprogram T cells
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10235-xStable and cell-specific transgene expression can be achieved through in vivo site-specific integration of large DNA payloads using a …
Magnetic resonance control of spin-correlated radical pair dynamics in vivo
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10282-4Magnetic resonance control of spin-correlated radical pairs alters red fluorescent protein emission in transgenic Caenorhabditis elegans, demonstrating in vivo …
Integrated memristor for mitigating reverse-bias in perovskite solar cells
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10275-3A memristor integrated into perovskite photovoltaics aims to mitigate the issues seen with reverse-bias degradation under partial shading.
Botanical mystery solved: how plants make a crucial malaria drug
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00891-4New evidence reveals biochemical pathway behind quinine production.
Affordable mobility for all: why we need smaller, cheaper electric vehicles
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00779-3A cross between e-bikes and electric cars, low-speed electric vehicles are easier to build and run and are greener …
AI set to map risks of future climate disasters
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00835-yWarning systems can engage people on a personal level — if they are built in a way that bridges …
Evolution
Nature, Published online: 18 March 2026; doi:10.1038/d41586-026-00612-xThe next in line.
Publisher Correction: Atlas-guided discovery of transcription factors for T cell programming
Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10382-1Publisher Correction: Atlas-guided discovery of transcription factors for T cell programming
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