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Prospective evaluation of genomics-guided off-label treatment
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10405-xEvaluation by the Drug Rediscovery Protocol of off-label use of 37 approved cancer drugs on 1,610 patients showed modest …
mRNA vaccines engage unconventional pathways in CD8<sup>+</sup> T cell priming
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10353-6mRNA–lipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T …
Tumour promotion through the lens of evolution
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10386-xThis Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations …
Ancient DNA reveals pervasive directional selection across West Eurasia
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10358-1Analysis of 15,836 ancient West Eurasian genomes reveals hundreds of instances of directional selection, showing that sustained changes in …
Brainwide blood volume reflects opposing neural populations
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10350-9Combined functional ultrasound imaging and Neuropixels recording of mouse brains identify two neuronal populations with opposing arousal-related activity and …
Identifying the topographic signature of early Martian oceans
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10381-2Shelves rather than shorelines may be better topographic indicators of oceans on Earth and Mars.
Linear RAG scanning mediates editing of Igκ variable region repertoires
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10362-5Studies explaining the secondary Igk recombination mechanism are described and Cer/Sis deletion and/or displacement is implicated as a developmental …
Giant cancer study reveals effectiveness of ‘off label’ treatments
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01241-0Genomics-guided trial could increase options for people undergoing cancer therapy — plus, a landmark ancient-genome study reveals natural selection …
Author Correction: HER2 expression identifies dynamic functional states within circulating breast cancer …
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10519-2Author Correction: HER2 expression identifies dynamic functional states within circulating breast cancer cells
Monolithic 3D integration of tantalum pentoxide nonlinear photonics
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10379-wMonolithic three-dimensional (3D) integration of tantalum pentoxide on a lithium niobate substrate enables scalable, multifunctional photonic systems and the …
Carbonyl swapping converts cyclic ketones to saturated heterocycles
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10508-5Carbonyl swapping converts cyclic ketones to saturated heterocycles
Editorial Expression of Concern: Creation of human tumour cells with defined genetic …
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10504-9Editorial Expression of Concern: Creation of human tumour cells with defined genetic elements
Retraction Note: The hidden fitness of the male zebra finch courtship song
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10483-xRetraction Note: The hidden fitness of the male zebra finch courtship song
Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10513-8Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes
Can China’s Great Green Wall shape efforts to keep the world’s deserts …
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01102-wGrand anti-desertification schemes often fail when trees die and funding dries up — yet one project has broken the …
What China’s Great Green Wall can teach the world
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01195-3Efforts to boost tree cover and restore degraded land globally need stable funding and time to learn from failure.
Dozens of AI disease-prediction models were trained on dubious data
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00697-4The models are designed to predict someone’s risk of diabetes or stroke. A few might already have been used …
Imaging interface-controlled bulk oxygen spillover
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10324-xIn situ microscopic single-particle imaging demonstrates the significance of rationally engineered metal–support interfaces for activating the oxygen in bulk …
Godzilla Minus Zero stomps through New York in first teaser trailer
*insert Godzilla screeching sound* Here's the very first look at the next big kaiju feature. Godzilla Minus Zero will continue the story of 2023's Godzilla …
Cuba could beat US energy blockade with $8bn investment in renewables, says …
Report by Common Wealth argues rest of the world should pay for country’s transition as reparative climate financeCuba could beat the US’s crippling energy blockade …
Chiang Mai’s New Year revelry hit by smog and war-related price spikes
Air pollution caused by wildfires is another blow to northern Thailand’s tourism industry as businesses suffer amid war in IranThe Doi Suthep temple in northern …
Pastries, but not kebabs, fall foul of UK junk food advertising ban
Watchdog bans Lidl pastry advertisement while items from kebab chain are cleared
UK’s Help to Buy housing scheme mainly benefited higher earners, says think …
Report by IFS says policy did little to increase affordability for those on lower incomes
Microsoft’s finally giving up on its massive Surface Hub touchscreen displays
Microsoft is reportedly ending production of its Surface Hub 3 collaborative office display and canceling plans for a Surface Hub 4, according to Windows Central. …
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